Well I can't really speak to the comfort of "22s on an X5M because I'm sitting on a set. It is presently near impossible to find the 335 rear for the "22. I know that there was a thread on this topic and they may be available now. I'm not sure since I have near new tires on my OEM 20s and am not looking.
You might want to look into availability of rubber before you buy.
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